“The exciting message is that because the pathophysiology is so similar, the last couple of decades in cancer therapy-related research can guide us to treatments that may help COVID brain fog.” Nerves’ insulation damaged The overlap between what happens in COVID-19’s cognitive aftermath and chemo brain, as it’s colloquially known, could be good news for patients because it may speed research on treatments, Monje said. The study’s lead authors are Anthony Fernandez-Castaneda, PhD, a postdoctoral scholar at Stanford Anna Geraghty, PhD, an instructor of neurology at Stanford and Peiwen Lu, PhD, and graduate student Eric Song, both of Yale. Monje shares senior authorship of the study with Akiko Iwasaki, PhD, professor of immunology and of molecular, cellular and developmental biology at Yale University. “We found that even mild COVID can cause prominent inflammation in the brain that dysregulates brain cells and would be expected to contribute to cognitive impairment,” said Michelle Monje, MD, PhD, professor of neurology and neurological sciences. The findings may help guide treatments for cognitive effects of COVID-19, the scientists said. The discovery, described in a paper that published online June 12 in Cell, relied on studies of mice with mild SARS-CoV-2 infection and postmortem human brain tissue collected early in the pandemic. DOI: 10.1111/ane.Brain fog after COVID-19 is biologically similar to cognitive impairment caused by cancer chemotherapy, something doctors often refer to as “chemo brain.” In both cases, excessive inflammation damages the same brain cells and processes, according to research led by Stanford University School of Medicine. Neurological manifestations of COVID-19: A systematic review and current update. A clinical primer for the expected and potential post-COVID-19 syndromes.
Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. news/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19
MSK researchers learn what’s driving ‘Brain fog’ in people with COVID-19.journals/jamaneurology/fullarticle/2764549 Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Some possible contributing factors include: However, there are other ways that COVID-19 may indirectly lead to brain fog as well. Other factors that may contribute to brain fogĪs mentioned above, inflammation in and around your brain may contribute to brain fog. They believe that these changes may also contribute to cognitive impairments. Researchers have also identified microstructural changes in the hippocampus and other areas of the brain after COVID-19. This may be one of the factors that contributes to brain fog. Inflammation in your brain hinders the ability of your neurons to communicate with each other. Cytokines are molecules produced by your immune system that encourage inflammation. Encephalopathy is a general term that refers to damage or disease of your brain.Ī study from January 2021 found increased levels of inflammatory cytokines in the fluid surrounding the brains of people weeks after their COVID-19 infection. Numerous case studies have found that some people who’ve had COVID-19 develop complications such as altered consciousness or encephalopathy. The virus is neuro-invasive, meaning that it can enter your brain tissue. Once in your system, the coronavirus enters cells through an enzyme called angiotensin-converting enzyme 2 (ACE2) receptor.
Respiratory droplets from that person can enter your body through your nose, mouth, or eyes. The new coronavirus that causes COVID-19, known as SARS-CoV-2, is thought to typically spread through close contact with someone who has the infection. It’s thought that both physiological and psychological factors may play a role. Researchers are still investigating the potential cause of brain fog in people who’ve had COVID-19.
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